HORDB

ID: hor003914
Uniprot ID: P01192
Protein name: Melanocyte-stimulating hormone alpha
Gene name: pomc
Organism: Sus scrofa (Pig)
Family: POMC family
Source: animal
Expression: ACTH and MSH are produced by the pituitary gland.
Disease: NA
Comments: NA
Taxonomy: Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway; GO:2000852 regulation of corticosterone secretion
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030141 secretory granule

Sequence: SYSMEHFRWGKPV
Length: 13
Propeptide: MPRLCGSRSGALLLTLLLQASMGVRGWCLESSQCQDLSTESNLLACIRACKPDLSAETPVFPGNGDAQPLTENPRKYVMGHFRWDRFGRRNGSSSGGGGGGGGAGQKREEEEVAAGEGPGPRGDGVAPGPRQDKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDELAEAFPLEFRRELAGAPPEPARDPEAPAEGAAARAELEYGLVAEAEAAEKKDEGPYKMEHFRWGSPPKDKRYGGFMTSEKSQTPLVTLFKNAIVKNAHKKGQ
Signal peptide: MPRLCGSRSGALLLTLLLQASMGVRG
Modification: T1 N-acetylserine;T13 Valine amide
Glycosylation: NA
Mutagenesis: NA

Function: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Mechanism: NA
Cross BBB: YES
Target: MC4R, MC3R
Target Unid: O97504, A5GFS7
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor003914_AF2.pdb

hor003914_ESM.pdb

Mass:	183805	Formula:	C75H106N20O19S
Absent amino acids:	ACDILNQT	Common amino acids:	S
pI:	9.3	Basic residues:	3
Polar residues:	4	Hydrophobic residues:	3
Hydrophobicity:	-92.31	Boman Index:	-2624
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	22.31
Instability Index:	3402.31	Extinction Coefficient cystines:	6990
Absorbance 280nm:	582.5